UNC scientists discover how chaperone enzyme plays a key role in cells' ability to tolerate DNA damage

UNC scientists who study how cells repair damage from environmental factors like sunlight and cigarette smoke have discovered how a “chaperone” enzyme plays a key role in cells’ ability to tolerate the DNA damage that leads to cancer and other diseases.

1.    Karolinska Institutet (the "Coordinator"), Sweden2.    Institut Curie, France3.    Danish Cancer Society, Denmark4.    Oslo Comprehensive Cancer Centre, Norway5.    Spanish National Cancer Centre, Spain6.    Istituto Nazionale dei Tumori, Italy7.    German Cancer Research Centre, Germany8.    Institut Gustave Roussy, France9.    International Agency for Research on Cancer, France10.  University of Oxford, UK11.  European Institute of Oncology, Italy12.  Christie NHS Foundation Trust, UK13.  National Institute of Oncology, Hungary14.  Netherlands Cancer Institute, Netherlands15.  Erasmus Medical Centre, Netherlands16.  Cambridge Cancer Research Institute, UK17.  Institut Jules Bordet, Belgium18.  European Molecular Biology Laboratory, Germany19.  Institute of Cancer Research, Royal Marsden Hospital, UK20.  Leiden University Medical Centre, Netherlands21.  Fundacion Instituto Valenciano de Oncologia, Spain22.  Istituto Tumori Bari, Italy23.  Fundacio Privada Institut d’Investigacio Oncologica de Vall Hebron, Spain24.  eCancer.eu, Switzerland25.  ECCO – The European CanCer Organisation, Belgium26.  Organisation of European Cancer Institutes, Belgium27.  European Cancer Patient Coalition, Netherlands28.  European Organisation for Research and Treatment of Cancer, Belgium

SOURCE Karolinska Institutet

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